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Inflammation:
The silent driver
of everything.

Chronic inflammation underlies almost every major disease - yet most people have no idea it's happening. Your wearable and daily data are already tracking it. Isabella reads the signals.

What is inflammation Silent signals HRV & inflammation Glucose Sleep Nutrition Correlations Blood tests Isabella insights FAQ
Your inflammation signals — today
HRV ⌚
34ms
↓ 5-day declining
−22% from baseline
Resting HR ⌚
78 bpm
↑ elevated 4 days
+11 above baseline
Skin temp. ⌚
+0.8°C
↑ overnight deviation
above 30-day avg
Glucose (CGM)
151
↑ post-meal mg/dL
3 spikes this week
Isabella · Inflammation pattern
"All four signals pointing the same direction - HRV down, resting HR up, skin temperature elevated, glucose spiking. Active systemic inflammation pattern. Review sleep and diet this week."
Track your inflammation signals →
7 of 10
Leading causes of death are
driven by chronic inflammation
hsCRP
The most actionable inflammation
blood marker - target under 1 mg/L
−22%
Average HRV reduction with elevated
CRP in population studies
40%
Reduction in inflammatory markers
with Mediterranean diet after 3 months
Understanding inflammation

Acute inflammation heals you.
Chronic inflammation kills you slowly.

The same biological system that fights infection and heals wounds - when persistently activated without resolution - becomes one of the most destructive forces in human health.

Acute vs chronic inflammation - same system, opposite outcomes
Acute inflammation — protective
⏱ Duration: Hours to days
🎯 Trigger: Injury, infection, pathogen
✓ Purpose: Remove threat, heal tissue
📊 CRP: Rises sharply, resolves quickly
❤️ HRV: Drops temporarily, recovers
⟺
Same system
Chronic inflammation — destructive
⏱ Duration: Months to decades
🎯 Trigger: Lifestyle, diet, stress, dysbiosis
✗ Outcome: Tissue damage, disease
📊 CRP: Persistently low-grade elevated
❤️ HRV: Chronically suppressed
01
Why is chronic inflammation so dangerous?
Chronic inflammation creates a persistent state of immune activation that gradually damages healthy tissue. Macrophages and neutrophils - the immune cells meant to neutralise threats - release reactive oxygen species and proteases that erode blood vessel walls, degrade joint tissue, damage neurons, and promote cellular mutations.

This is the unifying mechanism behind most major chronic diseases. Atherosclerosis is an inflammatory disease of the arteries. Type 2 diabetes is driven by inflammatory disruption of insulin signalling. Alzheimer's involves neuroinflammation. Many cancers develop in chronically inflamed tissue. Autoimmune conditions are a dysregulated inflammatory response turned against the body itself. Addressing chronic inflammation isn't treating one condition - it's protecting against all of them simultaneously.
Disease burden
A 2019 analysis published in Nature Medicine estimated that "inflammaging" - chronic low-grade inflammation associated with ageing and lifestyle - accounts for approximately 50% of all global mortality from non-communicable diseases including cardiovascular disease, diabetes, cancer, and chronic kidney disease.
02
What causes chronic low-grade inflammation?
Unlike acute inflammation (which has a clear trigger), chronic inflammation is driven by the accumulated burden of multiple lifestyle factors - each modest on its own, but compounding over time. The major drivers are:

Diet: Ultra-processed food, refined carbohydrates, seed oils high in omega-6, added sugar, and alcohol all activate inflammatory pathways.
Sleep deprivation: Even one night of poor sleep elevates IL-6 and TNF-α measurably.
Chronic stress: Sustained cortisol dysregulates the immune system, shifting it toward pro-inflammatory states.
Physical inactivity: Muscle contraction produces anti-inflammatory myokines - inactivity removes this suppressive signal.
Gut dysbiosis: LPS from disrupted gut bacteria crossing into circulation is one of the most potent triggers of systemic inflammation.
Visceral fat: Adipose tissue, especially around the abdomen, actively produces inflammatory cytokines (IL-6, TNF-α).
The compounding effect
Each inflammatory driver independently elevates hsCRP modestly. But their combined effect is multiplicative rather than additive. A person with poor sleep + high stress + processed diet + sedentary lifestyle can have hsCRP 8–10× higher than someone with none of these - despite each factor appearing "mild."
The silent signals

Inflammation is visible
in your daily data.

You don't need a blood test every week to track inflammation. Your wearable captures multiple proxy signals daily - and Isabella reads them together.

💓
HRV decline
Inflammatory cytokines (IL-6, TNF-α) suppress parasympathetic tone, reducing HRV. A 5-day declining trend - not a single dip - is the meaningful signal. Chronic low HRV correlates strongly with elevated hsCRP in population studies.
❤️
Elevated resting HR
Systemic inflammation activates the sympathetic nervous system and increases cardiac output - raising resting heart rate. Each 10 bpm increase in resting HR is associated with approximately 18% increased cardiovascular risk, partly mediated by inflammation.
🌡️
Skin temperature ↑
Overnight skin temperature deviation (tracked by Oura, Garmin, newer Apple Watch) is one of the most sensitive early inflammation signals - often rising 12–24 hours before you feel unwell. Even a persistent +0.3–0.5°C above baseline is meaningful.
🌬️
Respiratory rate ↑
Inflammatory cytokines stimulate respiratory drive via the brainstem. Elevated overnight respiratory rate (above your personal baseline) reflects autonomic inflammation response - particularly associated with gut-driven and metabolic inflammation.
03
How reliable are wearable signals as inflammation proxies?
Individually, each wearable signal has moderate correlation with inflammatory markers. HRV is the most studied - population research consistently shows inverse relationships with hsCRP and IL-6. Resting HR elevation is associated with inflammatory disease burden. Skin temperature is emerging as highly sensitive for early inflammation, though individual variation is large.

The power comes from combining signals. When HRV declines, resting HR rises, sleep quality drops, and skin temperature elevates simultaneously over several days - the probability of elevated inflammatory markers is substantially higher than any single signal alone. This is exactly what Isabella watches for: convergence, not individual readings.
The HRV-CRP relationship
A 2017 meta-analysis of 14 studies (n=14,838) found a significant inverse association between HRV and hsCRP - people with lower HRV had consistently higher inflammatory markers. The relationship was independent of age, sex, BMI, and smoking status, suggesting HRV captures a direct physiological effect of inflammation on autonomic function.
04
Does inflammation affect sleep, or does poor sleep cause inflammation?
Both - and the relationship is bidirectional and self-reinforcing. Even a single night of insufficient sleep (under 6 hours) elevates IL-6, TNF-α, and hsCRP measurably the following day. This inflammatory response then disrupts the next night's sleep through cytokine-mediated sleep architecture changes - particularly suppressing slow-wave sleep, which is when cellular repair occurs.

People with chronic poor sleep have systematically elevated inflammatory markers compared to adequate sleepers, even after controlling for other lifestyle factors. The mechanism involves two pathways: direct cytokine elevation from sleep deprivation, and increased sympathetic activity (lower HRV) that activates inflammatory transcription factors like NF-κB.
  • Track sleep consistency alongside HRV - the combination is more predictive than either alone
  • Slow-wave and REM sleep are the anti-inflammatory sleep stages - fragmented sleep reduces both
  • Alcohol impairs slow-wave sleep even when it helps initial sleep onset - a hidden inflammatory driver
  • Consistent sleep timing (same wake time daily) reduces the inflammatory burden of irregular sleep schedules
HRV & inflammation

Your HRV is your daily
inflammation report.

HRV is not a fitness metric. It is a measure of autonomic nervous system balance - and inflammation is one of its most potent modulators. Improving your inflammatory profile raises HRV. Reliably.

How inflammatory cytokines suppress HRV - the mechanism
Trigger
Poor diet · stress · bad sleep · gut dysbiosis
→
Cytokines released
IL-6 · TNF-α · IL-1β activate NF-κB
→
Vagal tone ↓
Parasympathetic suppressed → HRV falls
The reverse is also true: reducing inflammation raises vagal tone and measurably improves HRV over 4–12 weeks
05
How do I use HRV to track my inflammatory status?
The key is your personal trend - not your absolute number. A reading of 35ms might be normal for one person and a sign of significant autonomic suppression for another. What matters is sustained deviation from your own rolling baseline.

Isabella establishes your 30-day HRV baseline and flags when you're in sustained decline (3+ consecutive days trending down). This is more predictive than single-day variation, which is normal. For inflammation tracking specifically, look at your 7-day and 30-day trend lines rather than individual morning readings.
  • A gradual upward HRV trend over 4–8 weeks is one of the best signals that your anti-inflammatory interventions are working
  • Alcohol reliably drops HRV the night of consumption - a useful n=1 experiment for your own sensitivity
  • High-intensity exercise temporarily suppresses HRV before it rises - don't confuse training stress with inflammatory stress
  • Combining HRV with resting HR gives a fuller picture - both moving in the wrong direction simultaneously is more significant than either alone
06
What lifestyle changes most reliably raise HRV through inflammation reduction?
The interventions with strongest evidence for both reducing inflammation and raising HRV:

1. Sleep consistency - the single most impactful. Consistent 7–9 hours with regular timing produces the largest HRV improvements in most people.
2. Exercise - aerobic exercise 3–5×/week raises HRV over 8–12 weeks. The first few weeks may see temporary HRV drops from training stress before the anti-inflammatory benefits emerge.
3. Dietary pattern shift - Mediterranean diet reduces hsCRP by ~30–40% and raises HRV measurably over 3 months.
4. Stress reduction - chronic psychological stress is a major cytokine driver. Meditation, breathwork, and even nature walks show HRV improvements in RCTs.
5. Gut health - reducing gut dysbiosis reduces LPS circulation, removing one of the most potent inflammatory drivers.
Exercise timing
Regular moderate aerobic exercise reduces hsCRP by an average of 0.33 mg/L and raises HRV significantly over 12 weeks in sedentary individuals. The effect is dose-dependent up to approximately 150 minutes per week - beyond which additional volume provides diminishing returns on inflammatory markers (though fitness continues to improve).
Glucose & inflammation

Every glucose spike is
an inflammatory event.

Post-meal glucose elevation triggers a cascade of inflammatory reactions. Repeated daily, this becomes one of the most significant drivers of chronic systemic inflammation - and one of the most trackable.

07
How does a glucose spike trigger inflammation?
When blood glucose rises sharply above approximately 140 mg/dL, several inflammatory mechanisms activate simultaneously. First, excess glucose binds to proteins and lipids non-enzymatically, forming advanced glycation end-products (AGEs). AGEs bind to their receptor (RAGE), directly activating NF-κB - the master switch of inflammatory gene expression. Second, glucose spikes generate reactive oxygen species (ROS) through mitochondrial overload, causing oxidative stress that damages endothelial cells. Third, high glucose impairs white blood cell function, triggering a compensatory inflammatory response.

Critically, glucose variability - the amplitude of swings - is independently inflammatory even when average glucose levels are normal. A person with frequent 162 mg/dL peaks who returns to baseline has higher inflammatory markers than someone with a flat 126 mg/dL profile at the same average.
The AGE mechanism
Advanced glycation end-products (AGEs) formed during glucose spikes are detectable in blood and directly proportional to the frequency and amplitude of post-meal glucose elevation. AGEs accumulate in tissue over years - stiffening arteries, cross-linking collagen, and maintaining a chronic inflammatory state independent of current glucose levels.
08
What glucose patterns most drive inflammation?
Three CGM patterns are most clinically meaningful from an inflammation perspective:

1. High post-meal peaks (above 140 mg/dL) - even brief spikes activate inflammatory pathways. The more frequent, the more cumulative damage.
2. High glucose variability - large swings (high peaks and low troughs) appear more damaging than sustained mild elevation, likely because the oscillation itself generates oxidative stress independently of the absolute values.
3. Elevated fasting glucose trends - a creeping fasting glucose (even within the "normal" range of 79–99 mg/dL) indicates worsening insulin resistance, which is both caused by and accelerates inflammation through visceral fat accumulation.
  • Eat protein and vegetables before carbohydrates at every meal - reduces peak glucose by up to 30%
  • A 10–20 minute walk after meals is one of the most evidence-backed glucose-lowering interventions
  • Vinegar or lemon juice before carbohydrate-heavy meals blunts glucose response through acetic acid
  • Consistent meal timing reduces glucose variability even without changing food quality
  • Identify your personal high-spike foods via CGM - they vary significantly by individual
Sleep & inflammation

Sleep is your body's
primary anti-inflammatory drug.

During deep sleep, inflammatory cytokines are cleared, cellular repair occurs, and the glymphatic system flushes inflammatory waste from the brain. Cutting short this process - even occasionally - has measurable inflammatory consequences.

09
How much sleep loss does it take to raise CRP?
Less than most people expect. A single night of sleep restriction to 4 hours measurably elevates IL-6 and TNF-α the following day. A week of sleeping 6 hours (versus 8) produces CRP levels equivalent to a low-grade infection in many participants. The Whitehall II study - tracking 10,308 civil servants over years - found that people who reduced sleep from 7 to 5 hours had nearly double the mortality risk, with inflammatory dysregulation as a key mechanism.

The inflammatory effect of poor sleep is cumulative. "Catching up" on weekends partially compensates, but does not fully reverse the inflammatory consequences of a week of short sleep.
Slow-wave sleep and inflammation
Slow-wave (deep) sleep specifically governs inflammatory regulation. Growth hormone, released almost exclusively during slow-wave sleep, has potent anti-inflammatory effects. Alcohol, late meals, and high stress all suppress slow-wave sleep specifically - explaining why they raise inflammatory markers even when total sleep time is maintained.
10
What wearable sleep metrics most correlate with inflammation?
Not all sleep data is equally useful for inflammation tracking. The most informative metrics from wearables:

Sleep efficiency - time asleep / time in bed. Below 85% consistently suggests fragmented sleep with reduced slow-wave content.
HRV during sleep - specifically the overnight HRV trend. Healthy sleep shows a characteristic U-shape, rising through the night as recovery occurs. A flat or declining overnight HRV is a sensitive inflammation signal.
Resting heart rate during sleep - elevated sleeping HR (even 3–5 bpm above baseline) is associated with inflammatory activation overnight.
Skin temperature deviation - persistently elevated overnight temperature (even +0.3°C) is one of the earliest signs of inflammatory burden increase.
  • Target 7–9 hours with a consistent wake time - timing consistency reduces CRP independently of duration
  • Avoid alcohol within 3 hours of sleep - it selectively destroys slow-wave sleep while appearing to improve sleep onset
  • A cool bedroom (around 18°C) promotes slow-wave sleep and reduces skin temperature elevation
  • Track your resting HR during sleep - a gradually rising trend over weeks signals accumulating inflammatory burden
Nutrition & inflammation

Food is your most powerful
anti-inflammatory tool.

What you eat drives inflammation more directly than almost any other lifestyle factor. The evidence base is large and consistent - and the translation to daily habits is straightforward.

Pro-inflammatory foods
🍩
Added sugar & refined carbohydrates
Rapid glucose spikes → AGE formation → NF-κB activation. The most direct dietary pathway to inflammation.
🛢️
Industrial seed oils high in omega-6
Excess linoleic acid (soybean, sunflower, corn oil) is the precursor to pro-inflammatory eicosanoids (PGE2, LTB4).
🍟
Ultra-processed food
Emulsifiers disrupt gut barrier → LPS entry → systemic inflammation. Low fibre simultaneously starves anti-inflammatory gut bacteria.
🍺
Alcohol
Increases intestinal permeability, elevates LPS, suppresses slow-wave sleep, and directly raises CRP. Dose-dependent.
🥩
Processed red meat
Processed meats (bacon, sausage, deli meat) elevate CRP and IL-6 in consistent observational and intervention data.
Anti-inflammatory foods
🐟
Fatty fish (salmon, mackerel, sardines)
EPA and DHA directly inhibit pro-inflammatory eicosanoid synthesis. Strongest single dietary anti-inflammatory agent. Target 2–3 portions/week.
🫒
Extra-virgin olive oil
Oleocanthal inhibits the same enzyme (COX) as ibuprofen. Polyphenols inhibit NF-κB and reduce hsCRP measurably.
🫐
Colourful berries & vegetables
Polyphenols (quercetin, resveratrol, anthocyanins) inhibit multiple inflammatory pathways. Variety of colours = variety of anti-inflammatory compounds.
🥜
Walnuts & almonds
Walnuts specifically contain ALA (plant omega-3) and polyphenols. Nut consumption consistently associated with lower CRP in meta-analyses.
🫘
Legumes & whole grains
High-fibre foods feed butyrate-producing gut bacteria, maintaining gut barrier integrity and reducing LPS-driven inflammation systemically.
The Mediterranean diet — the strongest evidence base
The Mediterranean dietary pattern - high in olive oil, vegetables, legumes, fish, and whole grains, low in processed food - has the most consistent RCT evidence for reducing systemic inflammation. A 2020 meta-analysis of 41 trials found Mediterranean diet adherence reduced hsCRP by an average of 1.17 mg/L, IL-6 by 0.58 pg/mL, and TNF-α by 1.4 pg/mL. Track your nutrition with Isabella →
✓−1.17 mg/L average hsCRP reduction
✓−0.58 pg/mL IL-6 reduction
✓40% reduction in cardiovascular events in the PREDIMED trial
✓Effects visible on blood markers within 3 months of consistent adherence
How the signals connect

Every signal is connected.
Isabella sees the whole picture.

Daily inflammatory drivers
🍩
High glucose spike
Post-meal above 7.8 mmol/L
😴
Poor sleep
Under 6 hrs or fragmented
😰
Chronic stress
Sustained cortisol elevation
🛋️
Physical inactivity
Steps below personal baseline
🍺
Alcohol
Gut barrier disruption
🍟
Ultra-processed food
Low fibre, emulsifiers
🔬
Isabella
correlates
Combines wearable signals, CGM, nutrition log, and lab results
"When 3+ drivers are active simultaneously, systemic inflammation is almost certain."
Measurable inflammatory effects
HRV suppression
IL-6 and TNF-α reduce parasympathetic tone. Visible within 24–48 hours of inflammation onset.
Resting HR elevation
Sympathetic activation raises baseline cardiac output. Often precedes CRP elevation.
Skin temperature ↑
Peripheral vasodilation and inflammatory heat generation. One of the earliest wearable signals.
Sleep disruption
Cytokines disrupt sleep architecture, reducing slow-wave sleep - which itself produces more cytokines.
Elevated hsCRP
The lagging blood marker - confirms what wearable signals showed days earlier.
Fatigue & brain fog
Cytokine-induced "sickness behaviour" - the body conserving energy for the immune response.
A real week — how the inflammatory cascade looked for Marcus
Monday
🍺3 drinks
Gut barrier disrupted overnight. Sleep fragmented. No awareness yet.
HRV 52ms — normal
Tuesday
😴Sleep 5.4 hrs
Disrupted night. Skin temperature +0.6°C. Stress logged 7/10 at work.
HRV 44ms ↓
Wednesday
🍕Glucose 164 mg/dL
Skipped lunch, ate pizza late. Big glucose spike. Resting HR +8 bpm.
HRV 38ms ↓↓
Thursday
🛋️Steps: 1,200
Too tired to exercise. Fatigue and brain fog. Isabella flags all 4 signals active.
HRV 34ms — alert
Isabella acts
🔬Pattern identified
4 inflammatory drivers stacked in 3 days. HRV down 35%. Suggests active inflammation. Recommends: sleep, walk, anti-inflammatory meal.
⚡ Day 3 of cascade
Blood tests

The blood markers that confirm
what your wearable suspected.

Wearable signals are leading indicators - they show inflammation building. Blood tests are confirming markers - they quantify what's already elevated. Together they give a complete picture.

Primary inflammation markers
hsCRP (high-sensitivity CRP)
Essential
The most actionable inflammation blood marker. Produced by the liver in response to IL-6. Target: under 1 mg/L optimal. 1–3 mg/L intermediate risk. Above 3 mg/L high risk. Request high-sensitivity CRP - standard CRP is less useful for lifestyle monitoring.
<1 mg/L optimal1–3 mg/L intermediate>3 mg/L high risk
Fasting insulin & HOMA-IR
Insulin resistance is both a cause and consequence of chronic inflammation. Elevated fasting insulin (above ~8–10 µIU/mL) with normal fasting glucose indicates early insulin resistance - one of the most actionable metabolic-inflammatory biomarkers. HOMA-IR (fasting glucose × fasting insulin ÷ 405) above 2.0 warrants attention.
Ferritin
Ferritin is an acute phase reactant - it rises with inflammation independently of iron status. Persistently elevated ferritin (above 200 ng/mL in women, 300 in men) in the absence of iron deficiency signals active systemic inflammation. Tracking it alongside hsCRP distinguishes iron deficiency from inflammatory elevation.
Supporting markers
HbA1c
3-month glucose average
Reflects average glucose over the past 3 months - a cumulative marker of AGE formation and glycaemic stress. Target below 5.4% for optimal metabolic health. Values between 5.7–6.4% indicate prediabetes and accelerated inflammatory damage.
Homocysteine
Elevated homocysteine (above 10 µmol/L) independently activates endothelial inflammation and is associated with cardiovascular disease, cognitive decline, and bone loss. Driven by B12, folate, and B6 insufficiency - all common and correctable. Responds rapidly to supplementation.
Vitamin D (25-OH) & Omega-3 index
Vitamin D deficiency (below 30 ng/mL) impairs immune regulation and is associated with elevated CRP. Omega-3 index (the ratio of EPA+DHA in red blood cell membranes) below 4% indicates insufficient anti-inflammatory fatty acid status. Both are highly prevalent deficiencies and directly correctable.
How Isabella connects your wearable signals to your lab results
HRV declining trend
→ Suggests elevated IL-6 / TNF-α. Check hsCRP and ferritin next labs.
Elevated resting HR + poor sleep
→ Sympathetic dominance pattern. Check hsCRP, fasting insulin, and cortisol.
Repeated glucose spikes (CGM)
→ AGE accumulation risk. Check HbA1c, fasting insulin, HOMA-IR, and hsCRP.
Skin temperature elevated
→ Peripheral inflammation signal. Check hsCRP, ferritin, and full blood count.
Real patterns — what Isabella found

How three people discovered
their inflammation driver.

Each person's primary inflammatory driver was different. Isabella identified it only because all signals were tracked together.

MR
Marcus R., 44*
Consultant · Fatigue & brain fog
Glucose
The problem

Marcus had persistent afternoon fatigue and brain fog. His sleep was good, he exercised regularly, and he didn't smoke or drink much. His standard annual blood test showed everything "normal."

What Isabella found

CGM revealed post-lunch glucose peaks of 169 mg/dL every day - driven by a large sandwich followed by fruit. His HRV dipped 18% on high-glucose days and his skin temperature elevated overnight those same evenings. Standard CRP was normal; hsCRP was 2.8 mg/L - clinically elevated.

Isabella's insight

"Your afternoon fatigue correlates precisely with your lunch glucose spike - 169 mg/dL daily. Your HRV drops 18% on high-spike days. Changing your meal order (protein and salad before the bread) should reduce the peak by 25–30% and eliminate the crash."

Glucose peak
9.4 mmol
before change
After 4 weeks
6.2 mmol
peak eliminated
PH
Priya H., 38*
Nurse · Low HRV, joint stiffness
Sleep
The problem

Priya had chronically low HRV (averaging 29ms), morning joint stiffness, and frequent infections. She assumed this was genetic or work-related. Her diet was genuinely good. She exercised 4× weekly.

What Isabella found

Priya was working 3 night shifts per week, sleeping during the day between 8am–3pm. Her sleep efficiency was 78% and her circadian rhythm was completely disrupted. On weeks without night shifts, her HRV averaged 41ms - her "low" HRV was entirely sleep-driven.

Isabella's insight

"Your HRV averages 41ms on non-shift weeks and 29ms on shift weeks. Your inflammation isn't dietary or genetic - it's circadian disruption. Every night shift resets your inflammatory clock. Supplementing with melatonin on shift nights and maximising sleep quality may reduce this significantly."

Shift week HRV
29ms
avg
Non-shift week
41ms
avg
TN
Thomas N., 52*
Executive · High hsCRP despite exercise
Gut
The problem

Thomas ran 5K three times weekly, ate well by most standards, didn't smoke, and drank moderately. His hsCRP was persistently 3.4 mg/L and his HRV was stuck at 33ms. His doctor had no explanation.

What Isabella found

Isabella's food log analysis found Thomas ate fewer than 8 different plant foods per week - his "healthy" diet was actually low in fibre diversity. He had no fermented foods. Stress log showed consistently elevated work stress. This gut-stress combination was the likely LPS driver. After 10 weeks of dietary changes, hsCRP dropped to 1.1 mg/L.

Isabella's insight

"Your exercise is protecting you - without it your CRP would likely be much higher. But your gut health is the missing piece. Under 8 plant foods per week and no fermented foods means your microbiome is likely producing the LPS driving your inflammation. This is very fixable."

hsCRP before
3.4 mg/L
high risk
After 10 weeks
1.1 mg/L
optimal
*Stories are inspired by real patient experiences and health patterns observed in care. Names, images, quotes, and certain details have been changed or combined to protect privacy. Individual experiences and outcomes may vary.
Find your inflammation driver with Isabella →
How Ziva helps

Your inflammation tracked
from every angle.

Inflammation doesn't show up in one place - it shows up in all your signals simultaneously. Isabella is the only tool that reads them together and tells you what's driving yours specifically.

What Isabella reads to build your inflammation picture
Wearable signals ⌚
HRV daily Resting HR Skin temp. Resp. rate Sleep quality Steps
Metabolic & CGM
Blood glucose Post-meal peaks Glucose variability Fasting glucose
Nutrition & lifestyle
Food & meal log Stress log Alcohol log Recovery score
Lab results
hsCRP HbA1c Fasting insulin Vitamin D Homocysteine
💓
Multi-signal inflammation alert
Isabella watches all four wearable signals simultaneously. When HRV declines AND resting HR rises AND skin temperature elevates AND sleep quality drops - all in the same 48–72 hour window - the inflammatory alert fires.
Isabella · Today

"4 signals converging - HRV down 22%, resting HR +11 bpm, skin temperature +0.8°C, sleep efficiency 76%. Active inflammation pattern. Review diet and stress this week."

📊
Glucose-inflammation correlation
CGM data correlated with HRV and resting HR shows exactly which foods drive your inflammatory response. Isabella identifies your personal high-spike foods and their HRV impact - not generic GI tables.
Isabella · Food pattern

"On days with a lunch spike above 144 mg/dL, your next-morning HRV averages 6ms lower. That's a direct glucose-inflammation signal in your own data."

📈
Anti-inflammatory progress tracking
As your inflammation reduces, Isabella tracks the recovery: HRV baseline gradually rising, resting HR falling, skin temperature normalising. The trend over 4–12 weeks is your inflammation report - without waiting for a blood test.
Isabella · 8-week progress

"HRV baseline up from 34ms to 44ms over 8 weeks. Resting HR down 6 bpm. Skin temperature normalised. Your anti-inflammatory changes are working."

Frequently asked questions

Common questions about inflammation

Isabella AI

Your inflammation is
trackable. Let Isabella
find what's driving it.

HRV, resting heart rate, glucose, sleep, nutrition, and your labs - Isabella reads them all together and identifies your personal inflammatory pattern.

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